Article
CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype.
Journal of experimental & clinical cancer research : CR - 16 Feb 2022
Mancarella Serena, Serino Grazia, Gigante Isabella, Cigliano Antonio, Ribback Silvia, Sanese Paola, Grossi Valentina, Simone Cristiano, Armentano Raffaele, Evert Matthias, Calvisi Diego F, Giannelli Gianluigi
Abstract excerpt
BACKGROUND: Intrahepatic Cholangiocarcinoma (iCCA) is characterized by a strong stromal reaction playing a role in tumor progression. Thymus cell antigen 1 (THY1), also called Cluster of Differentiation 90 (CD90), is a key regulator of cell-cell and cell-matrix interaction. In iCCA, CD90 has been reported to be associated with a poor prognosis. In an iCCA PDX model, we recently found that CD90 was downregulated...
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