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Article

A framework for employing longitudinally collected multicenter electronic health records to stratify heterogeneous patient populations on disease history.

Journal of the American Medical Informatics Association : JAMIA - 13 Apr 2022

Maurits Marc P, Korsunsky Ilya, Raychaudhuri Soumya, Murphy Shawn N, Smoller Jordan W, Weiss Scott T, Huizinga Thomas W J, Reinders Marcel J T, Karlson Elizabeth W, van den Akker Erik B, Knevel Rachel

Abstract excerpt

OBJECTIVE: To facilitate patient disease subset and risk factor identification by constructing a pipeline which is generalizable, provides easily interpretable results, and allows replication by overcoming electronic health records (EHRs) batch effects. MATERIAL AND METHODS: We used 1872 billing codes in EHRs of 102 880 patients from 12 healthcare systems. Using tools borrowed from single-cell omics, we mitigated...

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PMID: 35139533
DOI: 10.1093/jamia/ocac008
PMCID: PMC9122640

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