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Article

Unique ER PR expression pattern in breast cancers with CHEK2 mutation: a hormone receptor and HER2 analysis based on germline cancer predisposition genes.

Breast cancer research : BCR - 8 Feb 2022

Wei Grace, Teng Mingxiang, Rosa Marilin, Wang Xia

Abstract excerpt

PURPOSE: Estrogen-receptor (ER) and progesterone-receptor (PR) expression levels in breast cancer, which have been principally compared via binomial descriptors, can vary widely across tumors. We sought to characterize ER and PR expression levels using semi-quantitative analyses of receptor staining in germline pathogenic variant (PV) carriers of cancer predisposition genes. METHODS: We conducted a retrospective...

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Identifiers

PMID: 35135604
DOI: 10.1186/s13058-022-01507-1
PMCID: PMC8822747

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