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Article

Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite.

Cell - 3 Feb 2022

Park Sun-Yang, Rao Chitong, Coyte Katharine Z, Kuziel Gavin A, Zhang Yancong, Huang Wentao, Franzosa Eric A, Weng Jing-Ke, Huttenhower Curtis, Rakoff-Nahoum Seth

Abstract excerpt

The human gut microbiota resides within a diverse chemical environment challenging our ability to understand the forces shaping this ecosystem. Here, we reveal that fitness of the Bacteroidales, the dominant order of bacteria in the human gut, is an emergent property of glycans and one specific metabolite, butyrate. Distinct sugars serve as strain-variable fitness switches activating context-dependent inhibitory...

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Identifiers

PMID: 35120663
DOI: 10.1016/j.cell.2022.01.002
PMCID: PMC8896310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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