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A novel DNA methylation signature associated with lymph node metastasis status in early gastric cancer

3 Feb 2022

Abstract excerpt

BACKGROUND: Lymph node metastasis (LNM) is an important factor for both treatment and prognosis of early gastric cancer (EGC). Current methods are insufficient to evaluate LNM in EGC due to suboptimal accuracy. Herein, we aim to identify methylation signatures for LNM of EGC, facilitate precision diagnosis, and guide treatment modalities. METHODS: For marker discovery, genome-wide methylation sequencing was...

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PMID: 35115040
DOI: 10.1186/s13148-021-01219-x

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