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FAdV-4 without Fiber-2 Is a Highly Attenuated and Protective Vaccine Candidate

2 Feb 2022

Abstract excerpt

Among all serotypes of fowl adenovirus, serotypes FAdV-1, FAdV-4, and FAdV-10 are unique members with two fiber genes ( fiber-1 and fiber-2 ). Recent studies reveal that Fiber-1, not Fiber-2, directly triggers viral infection of FAdV-4, whereas Fiber-2, but not Fiber-1, has been identified as the major virulence determiner and an efficient protective immunogen for subunit vaccines.

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PMID: 35107364
DOI: 10.1128/spectrum.01436-21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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