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Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration

25 Jan 2022

Abstract excerpt

BACKGROUND: Histone deacetylase 1 (HDAC1) belongs to class I histone deacetylases, which are zinc-dependent enzymes that remove the acetyl group from histones and other proteins providing epigenetic regulation of gene expression. It plays an important role in the hair follicle and epidermal homeostasis in addition to its immunomodulatory roles. Alopecia areata (AA) and acne vulgaris are common skin diseases in...

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PMID: 35076083
DOI: 10.1111/ajd.13784

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