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Article

Activation of the plant mevalonate pathway by extracellular ATP.

Nature communications - 21 Jan 2022

Cho Sung-Hwan, Tóth Katalin, Kim Daewon, Vo Phuc H, Lin Chung-Ho, Handakumbura Pubudu P, Ubach Albert Rivas, Evans Sterling, Paša-Tolić Ljiljana, Stacey Gary

Abstract excerpt

The mevalonate pathway plays a critical role in multiple cellular processes in both animals and plants. In plants, the products of this pathway impact growth and development, as well as the response to environmental stress. A forward genetic screen of Arabidopsis thaliana using Ca2+-imaging identified mevalonate kinase (MVK) as a critical component of plant purinergic signaling. MVK interacts directly with the...

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PMID: 35064110
DOI: 10.1038/s41467-022-28150-w
PMCID: PMC8783019

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