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Article

GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.

BMC bioinformatics - 10 Jan 2022

Wu Yu-Ching, Chen Chia-I, Chen Peng-Ying, Kuo Chun-Hung, Hung Yi-Hsuan, Peng Kang-Yung, Wu Vin-Cent, Tsai-Wu Jyy-Jih, Hsu Chia-Lang

Abstract excerpt

BACKGROUND: Glucocorticoid-remediable aldosteronism (GRA) is a form of heritable hypertension caused by a chimeric fusion resulting from unequal crossing over between 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), which are two genes with similar sequences. Different crossover patterns of the CYP11B1 and CYP11B2 chimeric genes may be associated with a variety of clinical presentations. It is...

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Share to Cytochrome P-450 CYP11B2
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Identifiers

PMID: 35012455
DOI: 10.1186/s12859-022-04561-w
PMCID: PMC8750845

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