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Thyroid Hormone Signalling in Human Evolution and Disease: A Novel Hypothesis

23 Dec 2021

Abstract excerpt

Thyroid hormone (TH) signalling is a universally conserved pathway with pleiotropic actions that is able to control the development, metabolism, and homeostasis of organisms. Using evidence from paleoecology/palaeoanthropology and data from the physiology of modern humans, we try to assess the natural history of TH signalling and its role in human evolution. Our net thesis is that TH signalling has likely played...

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PMID: 35011782
DOI: 10.3390/jcm11010043

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