A Common R219K Variant of ATP-Binding Cassette Transporter A1 Gene Alters Atherometabolic Traits in Pregnant Women With Gestational Diabetes Mellitus.

doi:10.3389/fendo.2021.782453

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Article

A Common R219K Variant of ATP-Binding Cassette Transporter A1 Gene Alters Atherometabolic Traits in Pregnant Women With Gestational Diabetes Mellitus.

Frontiers in endocrinology - 1 Jan 2021

Tang Fangmei, Guan Linbo, Liu Xinghui, Fan Ping, Zhou Mi, Wu Yujie, Liu Rui, Liu Yu, Liu Sixu, Li Dehua, Bai Huai

Abstract excerpt

Background: ATP-binding cassette transporter A1 (ABCA1) has important roles in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport, and is implicated in lipid-related disorders. Genetic variants are involved in the pathogenesis of gestational diabetes mellitus (GDM). The objective of this study was to investigate the association of rs2230806 (R219K), a single nucleotide polymorphism (SNP)...

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PMID: 34975757
DOI: 10.3389/fendo.2021.782453
PMCID: PMC8718706

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