Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mechanism of the lncRNA PTTG3P/miR-142-5p/JAG1 axis modulating tongue cancer cell phenotypes through the Notch1 signaling.

Cells & development - 1 Mar 2022

Zhang Tonghan, Liu Xiaoling, Su Kui, Zheng Qiaoyi, Liu Peng, Xu Zhijie, Zhang Yonghao

Abstract excerpt

Tongue cancer is the most prevalent type of oral cancer. Our previous study revealed that JAG1 exerted an oncogenic effect on tongue carcinoma through the JAG1/Notch pathway. In this study, a lncRNA PTTG3P which was upregulated in tongue cancer, was found to be positively correlated with JAG1. In CAL-27 and SCC4 cells, PTTG3P silencing significantly decreased JAG1 proteins and the ability of tongue tumor cells to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Jagged-1 Protein
Share to MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Receptor, Notch1

Share to RNA, Long Noncoding

Share to Signal Transduction

Share to Tongue Neoplasms

Source

Identifiers

PMID: 34952204
DOI: 10.1016/j.cdev.2021.203762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mechanism of the lncRNA PTTG3P/miR-142-5p/JAG1 axis modulating tongue cancer cell phenotypes through the Notch1 signaling.PMID 34952204Read ↗

Activation of Notch signaling in human tongue carcinomaSemantic proximity Read ↗

Regulatory role of miRNAs in nasopharyngeal cancer involving PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β‐catenin and pRB‐E2F signaling pathways: A reviewSemantic proximity Read ↗

ANLN promotes carcinogenesis in oral cancer by regulating PI3K/mTOR signaling pathwaySemantic proximity Read ↗

LINC00958 promotes the proliferation of TSCC via miR-211-5p/CENPK axis and activating the JAK/STAT3 signaling pathwaySemantic proximity Read ↗

NF-κB-Mediated lncRNA AC007271.3 as A ceRNA Promotes Carcinogenesis of Oral Squamous Cell Carcinoma by Regulating SlugSemantic proximity Read ↗

lncRNA SNHG8 promotes aggressive behaviors of nasopharyngeal carcinoma via regulating miR-656-3p/SATB1 axisSemantic proximity Read ↗

Role of SNHG7‐miR‐653‐5p‐STAT2 feedback loop in regulating neuroblastoma progressionSemantic proximity Read ↗

LncRNA TSIX acts as a ceRNA of miR-342-3p to Promote the Progression of Nasopharyngeal Carcinoma by Regulating AGR2Semantic proximity Read ↗

Long noncoding RNA PVT1 promoted gallbladder cancer proliferation by epigenetically suppressing miR-18b-5p via DNA methylationSemantic proximity Read ↗

TRAIP enhances progression of tongue squamous cell carcinoma through EMT and Wnt/β-catenin signaling by interacting with DDX39ASemantic proximity Read ↗

MIR106A-5p upregulation suppresses autophagy and accelerates malignant phenotype in nasopharyngeal carcinoma.Semantic proximity Read ↗

A transcriptomic analysis identifies the association of MIR31HG and EPB41L4A-AS2 lncRNAs in Oral CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.