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Article

Zebularine induces enzymatic DNA-protein crosslinks in 45S rDNA heterochromatin of Arabidopsis nuclei.

Nucleic acids research - 11 Jan 2022

Prochazkova Klara, Finke Andreas, Tomaštíková Eva Dvořák, Filo Jaroslav, Bente Heinrich, Dvořák Petr, Ovečka Miroslav, Šamaj Jozef, Pecinka Ales

Abstract excerpt

Loss of genome stability leads to reduced fitness, fertility and a high mutation rate. Therefore, the genome is guarded by the pathways monitoring its integrity and neutralizing DNA lesions. To analyze the mechanism of DNA damage induction by cytidine analog zebularine, we performed a forward-directed suppressor genetic screen in the background of Arabidopsis thaliana zebularine-hypersensitive structural...

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PMID: 34904670
DOI: 10.1093/nar/gkab1218
PMCID: PMC8754632

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