Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants.

doi:10.1126/science.abm0811

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Article

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants.

Science (New York, N.Y.) - 14 Jan 2022

Reynolds Catherine J, Gibbons Joseph M, Pade Corinna, Lin Kai-Min, Sandoval Diana Muñoz, Pieper Franziska, Butler David K, Liu Siyi, Otter Ashley D, Joy George, Menacho Katia, Fontana Marianna, Smit Angelique, Kele Beatrix, Cutino-Moguel Teresa, Maini Mala K, Noursadeghi Mahdad, Brooks Tim, Semper Amanda, Manisty Charlotte, Treibel Thomas A, Moon James C, McKnight Áine, Altmann Daniel M, Boyton Rosemary J

Abstract excerpt

The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting strain on downstream immunity to heterologous variants of concern (VOCs) is unknown. Studying a longitudinal healthcare worker cohort, we found that after three antigen exposures (infection plus two vaccine doses), S1 antibody, memory B cells, and heterologous neutralization of B.1.351, P.1, and B.1.617.2 plateaued,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34855510
DOI: 10.1126/science.abm0811
PMCID: PMC10186585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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