Article
Distinct microbiome profiles and biofilms in Leishmania donovani-driven cutaneous leishmaniasis wounds.
Scientific reports - 30 Nov 2021
Jayasena Kaluarachchi T D, Campbell Paul M, Wickremasinghe Rajitha, Ranasinghe Shalindra, Wickremasinghe Renu, Yasawardene Surangi, De Silva Hiromel, Menike Chandrani, Jayarathne M C K, Jayathilake Subodha, Dilhari Ayomi, McBain Andrew J, Weerasekera Manjula M
Abstract excerpt
The endemic strain of Leishmania donovani in Sri Lanka causes cutaneous leishmaniasis (CL) rather than more common visceral form. We have visualized biofilms and profiled the microbiome of lesions and unaffected skin in thirty-nine CL patients. Twenty-four lesions (61.5%) were biofilm-positive according to fluorescence in situ hybridization. Biopsies of biofilm-positive lesions were dominated by Pseudomonas,...
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