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Article

Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia.

International journal of biological macromolecules - 15 Jan 2022

Djulbegovic Mak B, Uversky Vladimir N, Karp Carol L, Harbour J William

Abstract excerpt

Mutations in the titin (TTN) gene are among the most common genomic aberrations in ocular surface squamous neoplasia (OSSN), the most common cancer of the external eye. Further, TTN mutations are associated with resistance to standard therapy with topical interferon alpha-2b (IFN-α2b). However, it remains unclear how TTN mutations drive OSSN pathogenesis and treatment resistance. TTN encodes the largest protein...

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Identifiers

PMID: 34838574
DOI: 10.1016/j.ijbiomac.2021.11.120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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