Article
A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes.
Nature communications - 18 Nov 2021
Darnaud Marion, De Vadder Filipe, Bogeat Pascaline, Boucinha Lilia, Bulteau Anne-Laure, Bunescu Andrei, Couturier Céline, Delgado Ana, Dugua Hélène, Elie Céline, Mathieu Alban, Novotná Tereza, Ouattara Djomangan Adama, Planel Séverine, Saliou Adrien, Šrůtková Dagmar, Yansouni Jennifer, Stecher Bärbel, Schwarzer Martin, Leulier François, Tamellini Andrea
Abstract excerpt
Mus musculus is the classic mammalian model for biomedical research. Despite global efforts to standardize breeding and experimental procedures, the undefined composition and interindividual diversity of the microbiota of laboratory mice remains a limitation. In an attempt to standardize the gut microbiome in preclinical mouse studies, here we report the development of a simplified mouse microbiota composed of 15...
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