The Influence of Genotype on the Phenotype, Clinical Course, and Risk of Adverse Events in Children with Hypertrophic Cardiomyopathy.

doi:10.1016/j.hfc.2021.07.013

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Article

The Influence of Genotype on the Phenotype, Clinical Course, and Risk of Adverse Events in Children with Hypertrophic Cardiomyopathy.

Heart failure clinics - 1 Jan 2022

Girolami Francesca, Passantino Silvia, Verrillo Federica, Palinkas Eszter Dalma, Limongelli Giuseppe, Favilli Silvia, Olivotto Iacopo

Abstract excerpt

Genetic testing in children with hypertrophic cardiomyopathy (HCM) can modify clinical management and lifestyle counseling. However, predicting long-term outcome and response to management in individual patients remains challenging, because of the peculiar genetic heterogeneity of the disease in the pediatric age range. Children with HCM secondary to an inborn error of metabolism or malformation syndromes tend to...

Topics

Cardiac Myosins
Cardiomyopathy, Hypertrophic
Child
Genotype
Humans
Myosin Heavy Chains
Phenotype

Source

Open in PubMed

Identifiers

PMID: 34776071
DOI: 10.1016/j.hfc.2021.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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