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Article

Development of a real-time PCR assay to detect the single nucleotide polymorphism causing Warmblood Fragile Foal Syndrome.

PloS one - 1 Jan 2021

Flanagan Sharon, Rowe Áine, Duggan Vivienne, Markle Erin, O'Brien Maureen, Barry Gerald

Abstract excerpt

Warmblood Fragile Foal syndrome (WFFS) is an autosomal recessive condition that affects the maturation of collagen in affected foals. Foals affected with the disease typically die or are euthanised shortly after birth. WFFS is caused by a single nucleotide change at position 2032 of the equine PLOD1 gene, causing an impairment of the wild-type enzyme. A commercial test for the causative genetic mutation is...

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Identifiers

PMID: 34748589
DOI: 10.1371/journal.pone.0259316
PMCID: PMC8575260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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