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Mutations in the nAChR β1 subunit and overexpression of P450 genes are associated with high resistance to thiamethoxam in melon aphid, Aphis gossypii Glover.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Jan 2000

Zhang Huihui, Yang Hengli, Dong Wenyang, Gu Zixuan, Wang Cuicui, Chen Anqi, Shi Xueyan, Gao Xiwu

Abstract excerpt

The TMXR is a strain of melon aphids (Aphis gossypii Glover) that has extremely high resistance (resistance ratio > 2300 fold) to thiamethoxam. We explored the basis of this resistance by examining differences in nicotinic acetylcholine receptors (nAChRs) and cytochrome P450 monooxygenase (CYP450s) between the TMXR and the susceptible strain. The results showed that two mutation sites of nAChR β1 subunit, V62I...

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PMID: 34737138
DOI: 10.1016/j.cbpb.2021.110682

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