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Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of organophosphates resistance in Aphis gossypii.

Environmental toxicology - 1 May 2014

Shang Qingli, Pan Yiou, Fang Kui, Xi Jinghui, Wong Andrew, Brennan James Andrew, Cao Chuanwang

Abstract excerpt

Aphis gossypii (Glover) has been found to possess multiple mutations in the acetylcholinesterase (AChE) gene (Ace) that might involve target site insensitivity. In vitro functional expression of AChEs reveals that the resistant Ace1 (Ace1R) and Ace2 (Ace2R) were significantly less inhibited by eserine, omethoate, and malaoxon than the susceptible Ace1 (Ace1S) and Ace2 (Ace2S). Furthermore, in both the mutant and...

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PMID: 22489048
DOI: 10.1002/tox.21778

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