Article
Identifying clinical phenotypes in extremely low birth weight infants-an unsupervised machine learning approach.
European journal of pediatrics - 1 Mar 2022
Matsushita Felipe Yu, Krebs Vera Lúcia Jornada, de Carvalho Werther Brunow
Abstract excerpt
There is increasing evidence that patient heterogeneity significantly hinders advancement in clinical trials and individualized care. This study aimed to identify distinct phenotypes in extremely low birth weight infants. We performed an agglomerative hierarchical clustering on principal components. Cluster validation was performed by cluster stability assessment with bootstrapping method. A total of 215 newborns...
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