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Article

The limits of personalization in precision medicine: Polygenic risk scores and racial categorization in a precision breast cancer screening trial.

PloS one - 1 Jan 2021

James Jennifer Elyse, Riddle Leslie, Koenig Barbara Ann, Joseph Galen

Abstract excerpt

Population-based genomic screening is at the forefront of a new approach to disease prevention. Yet the lack of diversity in genome wide association studies and ongoing debates about the appropriate use of racial and ethnic categories in genomics raise key questions about the translation of genomic knowledge into clinical practice. This article reports on an ethnographic study of a large pragmatic clinical trial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34714858
DOI: 10.1371/journal.pone.0258571
PMCID: PMC8555816

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