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Markers of Gut Barrier Function and Microbial Translocation Associate with Lower Gut Microbial Diversity in People with HIV.

Viruses - 22 Sept 2021

Ellis Ronald J, Iudicello Jennifer E, Heaton Robert K, Isnard Stéphane, Lin John, Routy Jean-Pierre, Gianella Sara, Hoenigl Martin, Knight Rob

Abstract excerpt

People with human immunodeficiency virus (HIV) (PWH) have reduced gut barrier integrity ("leaky gut") that permits diffusion of microbial antigens (microbial translocation) such as lipopolysaccharide (LPS) into the circulation, stimulating inflammation. A potential source of this disturbance, in addition to gut lymphoid tissue CD4+ T-cell depletion, is the interaction between the gut barrier and gut microbes...

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Identifiers

PMID: 34696320
DOI: 10.3390/v13101891
PMCID: PMC8537977

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CD4

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