Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion

12 Oct 2021

Abstract excerpt

Type 1 diabetes mellitus (T1DM) is associated with reduced fetal growth in early pregnancy, but a contributing role of the placenta has remained elusive. Thus, we investigated whether T1DM alters placental development in the first trimester. Using a protein array, the level of 60 cell-cycle-related proteins was determined in human first trimester placental tissue (gestational week 5–11) from control (n = 11) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Gestational Diabetes Research and Management
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34681648
DOI: 10.3390/ijms222010989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and InvasionPMID 34681648Read ↗

Effects of maternal diabetes on trophoblast cellsSemantic proximity Read ↗

MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1Semantic proximity Read ↗

Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell LevelSemantic proximity Read ↗

Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axisSemantic proximity Read ↗

Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell LevelSemantic proximity Read ↗

miR-132 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viabilitySemantic proximity Read ↗

The impact of hyperglycemia upon BeWo trophoblast cell metabolic function: A multi-OMICS and functional metabolic analysisSemantic proximity Read ↗

The interplay of inflammation and placenta in maternal diabetes: insights into Hofbauer cell expression patternsSemantic proximity Read ↗

The possible involvement of circRNA DMNT1/p53/JAK/STAT in gestational diabetes mellitus and preeclampsiaSemantic proximity Read ↗

Systematic Characterization of Autophagy in Gestational Diabetes MellitusSemantic proximity Read ↗

GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restrictionSemantic proximity Read ↗

Fetal endothelial dysfunction in Gestational Diabetes Mellitus under Dietary or Insulin therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.