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Cytotoxin‐associated gene A (CagA) promotes aortic endothelial inflammation and accelerates atherosclerosis through the NLRP3/caspase‐1/IL‐1β axis

20 Oct 2021

Abstract excerpt

Abstract Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between chronic infections and atherosclerosis triggered interests between these conditions. The seroepidemiological study showed that Helicobacter pylori strains that express cytotoxin‐associated gene A (CagA), an oncoprotein and a major virulence factor, was positively correlated with atherosclerosis and related clinical...

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PMID: 34670018
DOI: 10.1096/fj.202100695rr

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