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Article

Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population.

Experimental cell research - 1 Dec 2021

Yadav Manohar Lal, Ranjan Prashant, Das Parimal, Jain Dharmendra, Kumar Ashok, Mohapatra Bhagyalaxmi

Abstract excerpt

NODAL signaling plays an essential role in vertebrate embryonic patterning and heart development. Accumulating evidences suggest that genetic mutations in TGF-β/NODAL signaling pathway can cause congenital heart disease in humans. To investigate the implication of NODAL signaling in isolated cardiovascular malformation, we have screened 300 non-syndromic CHD cases and 200 controls for NODAL and ACVR1B by Sanger...

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PMID: 34666056
DOI: 10.1016/j.yexcr.2021.112869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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