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Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology

16 Oct 2021

Abstract excerpt

In currently ongoing adoptive T-cell therapies, T cells collected from the patient are given back to the patient after ex vivo cell activation and expansion. In some cases, T cells are transduced with chimeric antigen receptor (CAR) or T-cell receptor (TCR) genes during the ex vivo culture period. Although such strategies have been shown to be effective in some types of cancer, there remain issues to be solved;...

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PMID: 34661676
DOI: 10.1093/intimm/dxab091

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