Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study.

doi:10.1158/1940-6207.CAPR-20-0642

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Article

Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study.

Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2021

Furniss C Sloane, Yurgelun Matthew B, Ukaegbu Chinedu, Constantinou Pamela E, Lafferty Catherine C, Talcove-Berko Eliana R, Schwartz Alison N, Stopfer Jill E, Underhill-Blazey Meghan, Kenner Barbara, Nelson Scott H, Okumura Sydney, Law Sherman, Zhou Alicia Y, Coffin Tara B, Rodriguez Nicolette J, Uno Hajime, Ocean Allyson J, McAllister Florencia, Lowy Andrew M, Lippman Scott M, Klein Alison P, Madlensky Lisa, Petersen Gloria M, Garber Judy E, Goggins Michael G, Maitra Anirban, Syngal Sapna

Abstract excerpt

Up to 10% of patients with pancreatic ductal adenocarcinoma (PDAC) carry underlying germline pathogenic variants in cancer susceptibility genes. The GENetic Education Risk Assessment and TEsting (GENERATE) study aimed to evaluate novel methods of genetic education and testing in relatives of patients with PDAC. Eligible individuals had a family history of PDAC and a relative with a germline pathogenic variant in...

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PMID: 34625409
DOI: 10.1158/1940-6207.CAPR-20-0642
PMCID: PMC8563400

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