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Article

Possible association between SP-C mutations and lung cancer: Two case reports and review of literature.

Cancer treatment and research communications - 1 Jan 2021

Darawshy Fares, Rmeileh Ayman Abu, Kuint Rottem, Berkman Neville

Abstract excerpt

Surfactant protein C (SP-C) is one of four surfactant proteins produced by type II pneumocytes. Mutations in surfactant protein A are strongly associated with development of lung cancer. Mutations in the SP-C gene are rare and are associated with interstitial lung disease in the pediatric age group. We describe two patients with SP-C mutations who developed lung cancer. Both patients had concurrent interstitial...

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Identifiers

PMID: 34600418
DOI: 10.1016/j.ctarc.2021.100461

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