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Article

Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling Pipelines.

Viruses - 18 Sept 2021

Brandt David, Simunovic Marina, Busche Tobias, Haak Markus, Belmann Peter, Jünemann Sebastian, Schulz Tizian, Klages Levin Joe, Vinke Svenja, Beckstette Michael, Pohl Ehmke, Scherer Christiane, Sczyrba Alexander, Kalinowski Jörn

Abstract excerpt

Genomic surveillance of the SARS-CoV-2 pandemic is crucial and mainly achieved by amplicon sequencing protocols. Overlapping tiled-amplicons are generated to establish contiguous SARS-CoV-2 genome sequences, which enable the precise resolution of infection chains and outbreaks. We investigated a SARS-CoV-2 outbreak in a local hospital and used nanopore sequencing with a modified ARTIC protocol employing 1200 bp...

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Identifiers

PMID: 34578452
DOI: 10.3390/v13091870
PMCID: PMC8518987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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