Article
Two cases of Hailey-Hailey disease effectively treated with apremilast and a review of reported cases.
The Journal of dermatology - 1 Dec 2021
Yoto Ayumi, Makino Teruhiko, Mizawa Megumi, Matsui Yu, Takemoto Keita, Furukawa Fumina, Kataoka Kazuya, Nakano Hajime, Sawamura Daisuke, Shimizu Tadamichi
Abstract excerpt
Hailey-Hailey disease (HHD) is an autosomal dominant genetic disease caused by a mutation of the ATP2C1 gene. Corticosteroids, antibiotics or cyclosporine have been administered to reduce inflammation and prevent flare-ups, but the efficacy is not always sufficient. We herein report two cases of HHD effectively treated with apremilast and review the previous literature. Patient 1 was a 28-year-old male and...
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