Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High mutations in fatty acid metabolism contribute to a better prognosis of small-cell lung cancer patients treated with chemotherapy.

Cancer medicine - 1 Nov 2021

Lyu Qiong, Zhu Weiliang, Wei Ting, Ding Weimin, Cao Manming, Wang Qiongyao, Guo Linlang, Luo Peng, Zhang Jian

Abstract excerpt

BACKGROUND: The majority of patients with small-cell lung cancer (SCLC) show a good response in the early stages of treatment, but more than 90% of patients will develop drug resistance. Therefore, biomarkers are urgently needed to identify patients who can benefit from systemic treatment. METHODS: We prospectively enrolled 52 extensive-stage SCLC patients before treatment from a local hospital to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Etoposide

Share to Fatty Acid Synthases

Share to Fatty Acids

Share to Progression-Free Survival

Share to Sequence Analysis, RNA

Share to Small Cell Lung Carcinoma

Source

Open in PubMed Open full text

Identifiers

PMID: 34564955
DOI: 10.1002/cam4.4290
PMCID: PMC8559513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High mutations in fatty acid metabolism contribute to a better prognosis of small-cell lung cancer patients treated with chemotherapy.PMID 34564955Read ↗

Fatty acid metabolism-derived prognostic model for lung adenocarcinoma: unraveling the link to survival and immune responseSemantic proximity Read ↗

Applying machine learning algorithms to develop a survival prediction model for lung adenocarcinoma based on genes related to fatty acid metabolismSemantic proximity Read ↗

Detection of the Fatty Acid Metabolism‐Linked Genes in Lung Adenocarcinoma as Biomarkers for Clinical Prognosis and Immunotherapeutic TargetsSemantic proximity Read ↗

Genomic Features of Chinese Small Cell Lung CancerSemantic proximity Read ↗

Genomic features of Chinese small cell lung cancer.Semantic proximity Read ↗

Comprehensive Analysis of Alteration Landscape and Its Clinical Significance of Mitochondrial Energy Metabolism Pathway‐Related Genes in Lung CancersSemantic proximity Read ↗

SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.Semantic proximity Read ↗

EGFR Mutation Subtypes Modulate Distinct Metabolic Profiles and Clinical Outcomes in Lung Cancer: A Retrospective AnalysisSemantic proximity Read ↗

Mitochondrial metabolism as a potential novel therapeutic target for lung adenocarcinomaSemantic proximity Read ↗

Mitochondrial dysfunction rather than mtDNA sequence mutation is responsible for the multi-drug resistance of small cell lung cancer.Semantic proximity Read ↗

Reprogramming of Lipid Metabolism in Lung Cancer: An Overview with Focus on EGFR-Mutated Non-Small Cell Lung Cancer.Semantic proximity Read ↗

High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.