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Article

Mutational landscape of TRPC6, WT1, LMX1B, APOL1, PTPRO, PMM2, LAMB2 and WT1 genes associated with Steroid resistant nephrotic syndrome.

Molecular biology reports - 1 Nov 2021

Thakor Jinal M, Parmar Glory, Mistry Kinnari N, Gang Sishir, Rank Dharamshibhai N, Joshi Chaitanya G

Abstract excerpt

BACKGROUND: Nephrotic syndrome appears as a group of symptoms like proteinuria, edema and hyperlipidemia. Identification of monogenic forms revealed the physiology and pathogenesis of the SRNS. METHODS AND RESULTS: We performed Illumina panel sequencing of seven genes in 90 Indian patients to determine the role of these genetic mutations in nephrotic syndrome prognosis. Samtool was used for variants calling, and...

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DNA Mutational Analysis
Genes, Wilms Tumor
Laminin
LIM-Homeodomain Proteins
Nephrotic Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphotransferases (Phosphomutases)

Transcription Factors

TRPC6 Cation Channel

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PMID: 34546508
DOI: 10.1007/s11033-021-06711-4

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