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Article

Uncovering the impact of noncoding variants in neurodegenerative brain diseases.

Trends in genetics : TIG - 1 Mar 2022

Frydas Alexandros, Wauters Eline, van der Zee Julie, Van Broeckhoven Christine

Abstract excerpt

Neurodegenerative brain diseases (NBDs) are characterized by cognitive decline and movement impairments caused by neuronal loss in different brain regions. A large fraction of the genetic heritability of NBDs is not explained by the current known mutations. Genome-wide association studies identified novel disease-risk loci, adding to the genetic basis of NBDs. Many of the associated variants reside in noncoding...

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Identifiers

PMID: 34535299
DOI: 10.1016/j.tig.2021.08.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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