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LncRNA HCG18 Suppresses CD8 + T Cells to Confer Resistance to Cetuximab in Colorectal Cancer Via miR-20b-5p/PD-L1 Axis

1 Aug 2021

Abstract excerpt

Aim: We aimed to explore the effect of long noncoding RNA HCG18 in colorectal cancer (CRC). Materials & methods: Relative gene and protein expression were screened. Colony formation and flow cytometry assays were performed to determine proliferation and apoptosis. Dual luciferase and RNA immunoprecipitation assays were conducted to validate the interaction between indicated molecules. Xenograft in nude mice was...

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PMID: 34523356
DOI: 10.2217/epi-2021-0130

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