Article
The role of single nucleotide polymorphisms of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus: a systematic review and meta-analysis.
F1000Research - 1 Jan 2021
Azharuddin Azharuddin, Ilmawan Muhammad, Fajar Jonny Karunia, Fahriani Marhami, Mamada Sukamto S, Maliga Helnida Anggun, Nainu Firzan, Dhama Kuldeep, Harapan Harapan, Magetsari Rahadyan
Abstract excerpt
Background: The pathogenesis of herniated nucleus pulposus (HNP) is complex and may involve the wide variety of gene polymorphism. However, the reports from the existing studies are inconclusive. The objective of this study was to determine the role of single nucleotide polymorphisms (SNPs) in interleukin 1 alpha ( IL-1A), tumor necrosis factor-alpha ( TNF-A), and vitamin D receptor ( VDR) genes on the...
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