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Article

Investigating the role of EGF-CFC gene family in recurrent pregnancy loss through bioinformatics and molecular approaches.

Systems biology in reproductive medicine - 1 Dec 2021

Bremm João Matheus, Boquett Juliano André, Silva Michels Marcus, Kowalski Thayne Woycinck, Gomes Flávia Gobetti, Vianna Fernanda Sales Luiz, Vieira Sanseverino Maria Teresa, Fraga Lucas Rosa

Abstract excerpt

Recurrent pregnancy loss (RPL) is the most common reproductive failure, reaching 1-5% of women throughout their lives, and having unknown etiology in 50% of the cases. In humans, EGF-CFC1 (Epidermal Growth Factors & Cripto/FRL-1/Cryptic) gene family is composed by TDGF1 and CFC1, two developmental genes. The aim of this study was to investigate the role of EGF-CFC on RPL. To this, multiple approaches were...

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Identifiers

PMID: 34498535
DOI: 10.1080/19396368.2021.1965673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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