Article
Genetic features of precursor B-cell phenotype Burkitt leukemia with IGH-MYC rearrangement.
Cancer reports (Hoboken, N.J.) - 1 Jul 2022
Yoshida Masanori, Tomizawa Daisuke, Yoshimura Satoshi, Osumi Tomoo, Nakabayashi Kazuhiko, Ogata-Kawata Hiroko, Ishiwata Keisuke, Sato-Otsubo Aiko, Kimura Yui, Ito Shuichi, Matsumoto Kimikazu, Deguchi Takao, Kiyokawa Nobutaka, Yoshioka Takako, Hata Kenichiro, Kato Motohiro
Abstract excerpt
BACKGROUND: An atypical form of Burkitt leukemia/lymphoma (BL), BL with a phenotype of precursor B-cells (preBLL), is listed in the WHO Classification. Recent reports suggested that preBLL and classical BL could be distinguished by the differences in IG-MYC translocation architecture and an additional mutated genes profile. The characteristics of classical BL are IG-MYC by aberrant somatic hypermutation or class...
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