Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease

Abstract excerpt

BACKGROUND: Recent studies reported the responses of ustekinumab (UST) for the treatment of Crohn's disease (CD) differ among patients, while the cause was unrevealed. The study aimed to develop a prediction model based on the gene transcription profiling of patients with CD in response to UST. METHODS: The GSE112366 dataset, which contains 86 CD and 26 normal samples, was downloaded for analysis. Differentially...

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