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Low-dose Methotrexate Therapy Does Not Affect Semen Parameters and Sperm DNA

31 Aug 2021

Abstract excerpt

BACKGROUND: Methotrexate is widely used in inflammatory diseases during the patients' reproductive years. The effect on male fertility and sperm DNA integrity is largely unknown. We evaluated sperm DNA integrity and basic semen parameters according to the World Health Organization (WHO) in male patients with inflammatory diseases treated with methotrexate. METHODS: Semen samples from 14 patients on low-dose...

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PMID: 34463329
DOI: 10.1093/ibd/izab205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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