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Article

B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations.

Blood advances - 24 Aug 2021

Six Kathryn A, Gerdemann Ulrike, Brown Anna L, Place Andrew E, Cantor Alan B, Kutny Matthew A, Avagyan Serine

Abstract excerpt

Germline RUNX1 mutations underlie a syndrome, RUNX1-familial platelet disorder (RUNX1-FPD), characterized by bleeding symptoms that result from quantitative and/or qualitative defect in platelets and a significantly increased risk for developing hematologic malignancies. Myeloid neoplasms are the most commonly diagnosed hematologic malignancies, followed by lymphoid malignancies of T-cell origin. Here, we...

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Share to B-Lymphocytes
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to TET2 gene

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Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 34424323
DOI: 10.1182/bloodadvances.2021004653
PMCID: PMC8405188

Genes

RUNX1
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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