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Article

EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus.

Biochimie - 1 Dec 2021

Tsvetkov Vladimir, Varizhuk Anna, Kozlovskaya Liubov, Shtro Anna, Lebedeva Olga, Komissarov Andrey, Vedekhina Tatjana, Manuvera Valentin, Zubkova Olga, Eremeev Artem, Shustova Elena, Pozmogova Galina, Lioznov Dmitry, Ishmukhametov Aydar, Lazarev Vassili, Lagarkova Maria

Abstract excerpt

In the search for anti-SARS-CoV-2 drugs, much attention is given to safe and widely available native compounds. The green tea component epigallocatechin 3 gallate (EGCG) is particularly promising because it reportedly inhibits viral replication and viral entry in vitro. However, conclusive evidence for its predominant activity is needed. We tested EGCG effects on the native virus isolated from COVID-19 patients...

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Identifiers

PMID: 34389380
DOI: 10.1016/j.biochi.2021.08.003
PMCID: PMC8353982

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