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Article

Implementation of whole genome sequencing for tuberculosis diagnostics in a low-middle income, high MDR-TB burden country.

Scientific reports - 28 Jul 2021

Vogel Monica, Utpatel Christian, Corbett Caroline, Kohl Thomas A, Iskakova Altyn, Ahmedov Sevim, Antonenka Uladzimir, Dreyer Viola, Ibrahimova Ainura, Kamarli Chynara, Kosimova Dilorom, Mohr Vanessa, Sahalchyk Evgeni, Sydykova Meerim, Umetalieva Nagira, Kadyrov Abdylat, Kalmambetova Gulmira, Niemann Stefan, Hoffmann Harald

Abstract excerpt

Whole genome sequencing (WGS) is revolutionary for diagnostics of TB and its mutations associated with drug-resistances, but its uptake in low- and middle-income countries is hindered by concerns of implementation feasibility. Here, we provide a proof of concept for its successful implementation in such a setting. WGS was implemented in the Kyrgyz Republic. We estimated needs of up to 55 TB-WGS per week and chose...

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Share to Antitubercular Agents
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to High-Throughput Nucleotide Sequencing

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Source

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Identifiers

PMID: 34321545
DOI: 10.1038/s41598-021-94297-z
PMCID: PMC8319420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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