Article
Phenotypic/Genotypic Profile of OXA-10-Like-Harboring, Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated Pharmacokinetic/Pharmacodynamic In Vivo Models To Further Evaluate Enzyme Functionality and Clinical Implications.
Antimicrobial agents and chemotherapy - 17 Sept 2021
Gill Christian M, Brink Adrian, Chu Chun Yat, Coetzee Jennifer, Dimopoulos George, Moodley Clinton, Opperman Christoffel Johannes, Pournaras Spyros, Tenover Fred C, Tickler Isabella A, Tootla Hafsah Deepa, Vourli Sophia, Nicolau David P
Abstract excerpt
In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime human-simulated regimens (HSR) against modified carbapenem inactivation method (mCIM)-positive Pseudomonas aeruginosa isolates harboring different OXA-10-like subtypes were described. The murine thigh model assessed ceftazidime (2 g every 8 h [q8h] HSR) and cefepime (2 g and 1 g q8h HSR). Phenotypes were similar despite possessing OXA-10-like...
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