Article
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome.
Nature - 1 Jul 2021
Han Shuo, Van Treuren Will, Fischer Curt R, Merrill Bryan D, DeFelice Brian C, Sanchez Juan M, Higginbottom Steven K, Guthrie Leah, Fall Lalla A, Dodd Dylan, Fischbach Michael A, Sonnenburg Justin L
Abstract excerpt
Gut microorganisms modulate host phenotypes and are associated with numerous health effects in humans, ranging from host responses to cancer immunotherapy to metabolic disease and obesity. However, difficulty in accurate and high-throughput functional analysis of human gut microorganisms has hindered efforts to define mechanistic connections between individual microbial strains and host phenotypes. One key way in...
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