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Article

Prediction and interpretation of rare missense variant in OTOG associated with hearing loss.

Genomics - 1 Jul 2021

Askari Masomeh, Moradi Zahra, Mohammadi Mahsa, Lagzian Milad, Asgharzade Samira

Abstract excerpt

OTOG encodes for otogelin, a component of the tectorial membrane. This gene is associated with nonprogressive mild-to-moderate hearing loss. However, no studies have yet identified the association between OTOG variation and severe-to-profound hearing loss. Therefore, to address this issue, a family-based whole-exome sequencing strategy (WES) was carried out. Two unrelated Iranian families with non-syndromic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

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Source

Identifiers

PMID: 34118384
DOI: 10.1016/j.ygeno.2021.06.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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