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Generation of an induced pluripotent stem cell line (OGHFUi001-A) from a type 1 early infantile epileptic encephalopathy with ARX mutation.

Stem cell research - 1 May 2021

Jia Nan, Gong Xiaohui, Chen Jun, Yang Tong, Bao Chunxiao, Shen Jie, Xiao Xirong

Abstract excerpt

Type 1 early infantile epileptic encephalopathy (EIEE1) is a severe early-onset epileptic encephalopathy with arrest of psychomotor development caused by hemizygous mutations in the ARX gene, which encodes a transcription factor in fundamental brain developmental processes. A human induced pluripotent stem cell (iPSC) line, termed as OGHFUi001-A, was generated using non-integrating episomal vector technique from...

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Identifiers

PMID: 34087996
DOI: 10.1016/j.scr.2021.102367

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