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Article

Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer

1 Jan 2021

Abstract excerpt

Objective: Hypoxia is a significant feature of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug resistance. However, the spatial distribution of hypoxia-related heterogeneity in PDAC remains unclear. Methods: Spatial transcriptomics (STs), a new technique, was used to investigate the ST features of engrafted human PDAC in the ischemic hind...

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PMID: 34086429
DOI: 10.20892/j.issn.2095-3941.2021.0158

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