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Article

Hyperexpression of CDRs and HWP1 genes negatively impacts on Candida albicans virulence.

PloS one - 1 Jan 2021

Maras Bruno, Maggiore Anna, Mignogna Giuseppina, D'Erme Maria, Angiolella Letizia

Abstract excerpt

C. albicans is a commensal organism present in the human microbiome of more than 60% of the healthy population. Transition from commensalism to invasive candidiasis may occur after a local or a general failure of host's immune system. This transition to a more virulent phenotype may reside either on the capacity to form hyphae or on an acquired resistance to antifungal drugs. Indeed, overexpression of genes...

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Identifiers

PMID: 34061886
DOI: 10.1371/journal.pone.0252555
PMCID: PMC8168907

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